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Glucocerebrosidase-IN-1 (hydrochloride)

Glucocerebrosidase-IN-1 (compound 11a) hydrochloride is a potent and selective GCase (glucocerebrosidase) inhibitor, with an IC50 of 29.3 μM and a Ki of 18.5 μM. Glucocerebrosidase-IN-1 hydrochloride can be used for the research of Gaucher disease (GD) and Parkinson’s disease (PD) [1].

Product Specifications

CAS Number

[2279945-77-4]

UNSPSC

12352005

Target

Glycosidase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/glucocerebrosidase-in-1-hydrochloride.html

Purity

99.16

Solubility

DMSO : 12.5 mg/mL (ultrasonic)

Smiles

O[C@@H]1[C@@H](CCCCCCCC)NC[C@@H](O)[C@H]1O.[H]Cl

Molecular Formula

C13H28ClNO3

Molecular Weight

281.82

References & Citations

[1]Clemente F, et al. Glucocerebrosidase (GCase) activity modulation by 2-alkyl trihydroxypiperidines: Inhibition and pharmacological chaperoning. Bioorg Chem. 2020 May;98:103740.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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