Glucocerebrosidase-IN-1
Glucocerebrosidase-IN-1 (compound 11a) is a potent and selective GCase (glucocerebrosidase) inhibitor, with an IC50 of 29.3 μM and a Ki of 18.5 μM. Glucocerebrosidase-IN-1 can be used for the research of Gaucher disease (GD) and Parkinson’s disease (PD) [1].
Product Specifications
CAS Number
2279945-76-3
UNSPSC
12352005
Target
Glycosidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/glucocerebrosidase-in-1.html
Purity
99.65
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O[C@@H]1[C@@H](CCCCCCCC)NC[C@@H](O)[C@H]1O
Molecular Formula
C13H27NO3
Molecular Weight
245.36
References & Citations
[1]Clemente F, et al. Glucocerebrosidase (GCase) activity modulation by 2-alkyl trihydroxypiperidines: Inhibition and pharmacological chaperoning. Bioorg Chem. 2020 May;98:103740.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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