Glucocerebrosidase-IN-1

Glucocerebrosidase-IN-1 (compound 11a) is a potent and selective GCase (glucocerebrosidase) inhibitor, with an IC50 of 29.3 μM and a Ki of 18.5 μM. Glucocerebrosidase-IN-1 can be used for the research of Gaucher disease (GD) and Parkinson’s disease (PD) [1].

Product Specifications

CAS Number

[2279945-76-3]

UNSPSC

12352005

Target

Glycosidase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/glucocerebrosidase-in-1.html

Purity

99.65

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O[C@@H]1[C@@H](CCCCCCCC)NC[C@@H](O)[C@H]1O

Molecular Formula

C13H27NO3

Molecular Weight

245.36

References & Citations

[1]Clemente F, et al. Glucocerebrosidase (GCase) activity modulation by 2-alkyl trihydroxypiperidines: Inhibition and pharmacological chaperoning. Bioorg Chem. 2020 May;98:103740.