HSP90-IN-14

HSP90-IN-14 (compound 4) is a potent Hsp90 (heat shock protein 90) inhibitor, with a Kd of 0.26 μM. HSP90-IN-14 shows anti-influenza virus activity in MDCK cells, with EC50 values of 2.6, 3.9, and 17 μM for influenza A/H3N2, A/H1N1, and B, respectively[1].

Product Specifications

CAS Number

[1995132-67-6]

UNSPSC

12352005

Target

HSP; Influenza Virus

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/hsp90-in-14.html

Solubility

10 mM in DMSO

Smiles

O=C(O)C(NC1=CC=C2N=C(NC(C3=CC(Cl)=C(Cl)N3)=O)SC2=C1)=O

Molecular Formula

C14H8Cl2N4O4S

Molecular Weight

399.21

References & Citations

[1]Lamut A, et al. Anti-influenza virus activity of benzo[d]thiazoles that target heat shock protein 90. Bioorg Chem. 2020 May;98:103733.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

HSP90

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