AChE/HDAC-IN-1

COX-2-IN-23 (compound A10) is a potent both AChE and HDAC inhibitor with IC50 values of 0.12 and 0.23 nM. COX-2-IN-23 exhibits antioxidant activity and metal chelating properties. COX-2-IN-23 can be used in alzheimer's disease research[1].

Product Specifications

CAS Number

[2414053-06-6]

UNSPSC

12352005

Target

Cholinesterase (ChE) ; HDAC

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ache-hdac-in-1.html

Solubility

10 mM in DMSO

Smiles

O=C(NCCCNC1=C(CCCC2)C2=NC3=CC(Cl)=CC=C31)C4=CC=C(/C=C/C(NO)=O)C=C4

Molecular Formula

C26H27ClN4O3

Molecular Weight

478.97

References & Citations

[1]Xu A, et al. Tacrine-hydroxamate derivatives as multitarget-directed ligands for the treatment of Alzheimer's disease: Design, synthesis, and biological evaluation. Bioorg Chem. 2020 May;98:103721.