AChE-IN-20
AChE-IN-20 (compound M26) is a potent AChE inhibitor with IC50 value of 397.32 nM and with Ki value of 335.76 nM. AChE-IN-20 shows inhibition potency against hCA I , hCA II and α-GLY with IC50 values of 84.14, 69.24 and 52.08 nM and with Ki values of 97.86, 76.23 and 57.93 nM, respectively[1].
Product Specifications
CAS Number
2428389-65-3
UNSPSC
12352005
Target
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ache-in-20.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=C(NC2=NC(NC3=CC=C(S(=O)(N)=O)C=C3)=NC(NC4=CC=C(S(=O)(N)=O)C=C4)=N2)C=C1)O
Molecular Formula
C22H20N8O6S2
Molecular Weight
556.57
References & Citations
[1]Lolak N, et al. Synthesis, characterization, inhibition effects, and molecular docking studies as acetylcholinesterase, α-glycosidase, and carbonic anhydrase inhibitors of novel benzenesulfonamides incorporating 1,3,5-triazine structural motifs. Bioorg Chem. 2020 Jul;100:103897.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE
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