SKLB0565
SKLB0565 is a potent tubulin inhibitor. SKLB0565 shows significant anti-proliferative activity against CRC (colorectal carcinoma) cell lines, with IC50 values ranging from 0.012 μM to 0.081 μM. SKLB0565 causes G2/M phase arrest and mitochondria-mediated intrinsic apoptosis. SKLB0565 inhibits cell migration and disrupted the tube formation of HUVECs[1].
Product Specifications
CAS Number
2414607-10-4
UNSPSC
12352005
Target
Apoptosis; Microtubule/Tubulin
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sklb0565.html
Solubility
10 mM in DMSO
Smiles
O=C1C(CNC2=C3N=CN(C4CCCC4)C3=NC(Cl)=N2)=C(CC)C=C(CC)N1
Molecular Formula
C20H25ClN6O
Molecular Weight
400.91
References & Citations
[1]Hu X, et al. Design, synthesis and biological evaluation of a novel tubulin inhibitor SKLB0565 targeting the colchicine binding site. Bioorg Chem. 2020 Apr;97:103695.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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