DNA Gyrase-IN-4
DNA Gyrase-IN-4 (compound 8p) is a potent DNA gyrase inhibitor, with an IC50 of 0.13 μM. DNA Gyrase-IN-4 shows excellent antibacterial activity against Staphylococcus aureus, Listeria monocytogenes, Salmonella and Escherichia coli, with MIC values of 0.05, 0.05, 0.05, and 8 μg/mL, respectively[1].
Product Specifications
CAS Number
2416400-32-1
UNSPSC
12352005
Target
Bacterial; DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/dna-gyrase-in-4.html
Solubility
10 mM in DMSO
Smiles
O=C(C(C1=O)=CC2=C(O1)C=CC(Cl)=C2)OC(C3=CC=C(Cl)C=C3)C4=NC(C)=C(C)S4
Molecular Formula
C22H15Cl2NO4S
Molecular Weight
460.33
References & Citations
[1]Liu H, et al. Novel coumarin-thiazolyl ester derivatives as potential DNA gyrase Inhibitors: Design, synthesis, and antibacterial activity. Bioorg Chem. 2020 Jul;100:103907.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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