AChE-IN-19
Product Specifications
UNSPSC Description
AChE-IN-19 (compound A15) is a highly potent AChE inhibitor with an IC50 value of 0.56 μM, also inhibits Aβ aggregation. AChE-IN-19 has potent neuroprotective activities and nearly no toxicity on SH-SY5Y cells. AChE-IN-19 can be used for researching Alzheimer's disease[1].
Target Antigen
Amyloid-β; Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ache-in-19.html
Solubility
10 mM in DMSO
Smiles
O=C(OC1=CC(OC)=C2CCC(C3=CC(OC)=C(OC)C(OC)=C3)OC2=C1)/C=C/C4=CC=C(N(C)C)C=C4
Molecular Weight
519.59
References & Citations
[1]Shi S, et al. Semi-synthesis and biological evaluation of flavone hybrids as multifunctional agents for the potential treatment of Alzheimer's disease. Bioorg Chem. 2020 Jul;100:103917.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-147938/AChE-IN-19-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-147938/
Clinical Information
No Development Reported
CAS Number
2742707-36-2
Curated Selection
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