TP0556351

TP0556351 is a potent and selective matrix metalloproteinase-2 (MMP2) inhibitor with an IC50 value of 0.2 nM. TP0556351 reduces the amount of collagen in the lungs of a Bleomycin-induced pulmonary fibrosis mouse model. TP0556351 can be used for researching idiopathic pulmonary fibrosis (IPF) [1].

Product Specifications

CAS Number

2787582-17-4

UNSPSC

12352005

Target

MMP

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/tp0556351.html

Solubility

10 mM in DMSO

Smiles

CC(C[C@@H](C(N([C@H](C(N1CCC[C@H]1CC(N)=O)=O)CCC(O)=O)C)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC(CCCCNC(C2=CC=C(OC3=CC=C(C(N)=O)C=C3)C=C2)=O)=O)CCC(O)=O)=O)CC(O)=O)=O)CCN)=O)C

Molecular Formula

C50H70N10O16

Molecular Weight

1067.15

References & Citations

[1]Takeuchi T, et al. Discovery of Aryloxyphenyl-Heptapeptide Hybrids as Potent and Selective Matrix Metalloproteinase-2 Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis. J Med Chem. 2022 Jun 23;65 (12) :8493-8510.