Apoptotic agent-2
Apoptotic agent-2 (compound 14b) induces apoptosis by down-regulation of Bcl-2 and up-regulation of Bax and caspase-3. Apoptotic agent-2 exhibits anti-proliferative activities and can be used for cancer research[1].
Product Specifications
CAS Number
2482310-18-7
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; Caspase
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/apoptotic-agent-2.html
Solubility
10 mM in DMSO
Smiles
CC1=C(/N=N/C2=CC=C(Cl)C=C2)SC(N/N=C3C4=C(C5=NC6=CC=CC=C6N=C5\3)C=CC=C4)=N1
Molecular Formula
C25H16ClN7S
Molecular Weight
481.96
References & Citations
[1]Fayed EA, et al. In vitro cytotoxic activity of thiazole-indenoquinoxaline hybrids as apoptotic agents, design, synthesis, physicochemical and pharmacokinetic studies. Bioorg Chem. 2020 Jul;100:103951.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bax; Bcl-2; Caspase 3
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