Human enteropeptidase-IN-1
Human enteropeptidase-IN-1 (compound 6b) is a highly potent, orally active and low systemic exposure enteropeptidase inhibitor. Human enteropeptidase-IN-1 boosts the increase in fecal protein output, and exhibits potent body weight loss in diet-induced obese (DIO) rat model. Human enteropeptidase-IN-1 can be used for anti-obesity research[1].
Product Specifications
CAS Number
1802891-20-8
UNSPSC
12352005
Target
Enteropeptidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/human-enteropeptidase-in-1.html
Solubility
10 mM in DMSO
Smiles
OC(C[C@]1(CC(C2=CC(OC(C3=CC=C(C=C3)NC(N)=N)=O)=CC=C2)=NO1)C(O)=O)=O
Molecular Formula
C20H18N4O7
Molecular Weight
426.38
References & Citations
[1]Ikeda Z, et al. Design, Synthesis, and Biological Evaluation of a Novel Series of 4-Guanidinobenzoate Derivatives as Enteropeptidase Inhibitors with Low Systemic Exposure for the Treatment of Obesity. J Med Chem. 2022 Jun 23;65 (12) :8456-8477.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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