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VEGFR-2-IN-28

VEGFR-2-IN-28 (compound 12c) is a potent VEGFR-2 inhibitor with IC50 value of 0.83 μM. VEGFR-2-IN-28 induces apoptosis and has anticancer activity[1].

Product Specifications

CAS Number

[2447597-39-7]

UNSPSC

12352005

Target

Apoptosis; VEGFR

Type

Reference compound

Related Pathways

Apoptosis; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/vegfr-2-in-28.html

Solubility

10 mM in DMSO

Smiles

O=C(N(C1=CC=C([N+]([O-])=O)C=C1[N+]([O-])=O)N=C/2C)C2=C\C3=CN(C4=CC=CC=C4)N=C3C5=CC=CC([N+]([O-])=O)=C5

Molecular Formula

C26H17N7O7

Molecular Weight

539.46

References & Citations

[1]Dawood DH, et al. Synthesis and molecular docking study of new pyrazole derivatives as potent anti-breast cancer agents targeting VEGFR-2 kinase. Bioorg Chem. 2020 Aug;101:103916.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

VEGFR2/KDR/Flk-1

Curated Selection

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