VEGFR-2-IN-28
Product Specifications
UNSPSC Description
VEGFR-2-IN-28 (compound 12c) is a potent VEGFR-2 inhibitor with IC50 value of 0.83 μM. VEGFR-2-IN-28 induces apoptosis and has anticancer activity[1].
Target Antigen
Apoptosis; VEGFR
Type
Reference compound
Related Pathways
Apoptosis;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/vegfr-2-in-28.html
Solubility
10 mM in DMSO
Smiles
O=C(N(C1=CC=C([N+]([O-])=O)C=C1[N+]([O-])=O)N=C/2C)C2=C\C3=CN(C4=CC=CC=C4)N=C3C5=CC=CC([N+]([O-])=O)=C5
Molecular Weight
539.46
References & Citations
[1]Dawood DH, et al. Synthesis and molecular docking study of new pyrazole derivatives as potent anti-breast cancer agents targeting VEGFR-2 kinase. Bioorg Chem. 2020 Aug;101:103916.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-147926/VEGFR-2-IN-28-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-147926/
Clinical Information
No Development Reported
CAS Number
2447597-39-7
Curated Selection
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