VEGFR-2-IN-28
VEGFR-2-IN-28 (compound 12c) is a potent VEGFR-2 inhibitor with IC50 value of 0.83 μM. VEGFR-2-IN-28 induces apoptosis and has anticancer activity[1].
Product Specifications
CAS Number
[2447597-39-7]
UNSPSC
12352005
Target
Apoptosis; VEGFR
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/vegfr-2-in-28.html
Solubility
10 mM in DMSO
Smiles
O=C(N(C1=CC=C([N+]([O-])=O)C=C1[N+]([O-])=O)N=C/2C)C2=C\C3=CN(C4=CC=CC=C4)N=C3C5=CC=CC([N+]([O-])=O)=C5
Molecular Formula
C26H17N7O7
Molecular Weight
539.46
References & Citations
[1]Dawood DH, et al. Synthesis and molecular docking study of new pyrazole derivatives as potent anti-breast cancer agents targeting VEGFR-2 kinase. Bioorg Chem. 2020 Aug;101:103916.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
VEGFR2/KDR/Flk-1
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