HCAI/II-IN-3

HCAI/II-IN-3 (compound 5b) is a potent dual hCA I/II inhibitor with Ki values of 51.25, 13.15 and 42.18 nM for hCA I, hCA II and hCA IX. hCAI/II-IN-3 possesses anti-hypoxic activity against acute mountain sickness (AMS) and low cellular activity[1].

Product Specifications

CAS Number

[2480283-93-8]

UNSPSC

12352005

Target

Carbonic Anhydrase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/hcai-ii-in-3.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CSC(NC(C2=CC=C(S(=O)(N)=O)C=C2)=O)=N1)NC3CCCC3

Molecular Formula

C16H18N4O4S2

Molecular Weight

394.47

References & Citations

[1]Yang C, et al. N-Quinary heterocycle-4-sulphamoylbenzamides exert anti-hypoxic effects as dual inhibitors of carbonic anhydrases I/II. Bioorg Chem. 2020 Jul;100:103931.