PIM1-IN-7

PIM1-IN-7 (compound 6c) is a potent PIM-1 inhibitor, with an IC50 of 0.67 μM. PIM1-IN-7 shows the high cytotoxicity activity against HCT-116 and MCF-7 cells, with IC50 values of 42.9 and 7.68 μM, respectively[1].

Product Specifications

CAS Number

[2439168-72-4]

UNSPSC

12352005

Target

Pim

Type

Reference compound

Related Pathways

JAK/STAT Signaling

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pim1-in-7.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=C2N=C(C)C=C(C)N2N=C1NC3=CC=CC=C3)NC4=C(C)C=CC=C4C

Molecular Formula

C23H23N5O

Molecular Weight

385.46

References & Citations

[1]Philoppes JN, et al. New pyrazolopyrimidine derivatives with anticancer activity: Design, synthesis, PIM-1 inhibition, molecular docking study and molecular dynamics. Bioorg Chem. 2020 Jul;100:103944.