PIM1-IN-6
PIM1-IN-6 (compound 5h) is a potent PIM-1 inhibitor, with an IC50 of 0.60 μM. PIM1-IN-6 shows the high cytotoxicity activity against HCT-116 and MCF-7 cells, with IC50 values of 1.51 and 15.2 μM, respectively[1].
Product Specifications
CAS Number
2439168-69-9
UNSPSC
12352005
Target
Pim
Type
Reference compound
Related Pathways
JAK/STAT Signaling
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pim1-in-6.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C2NC(C=C(C3=CC=CC=C3)N2N=C1NCC)=O)NC4=CC=C([N+]([O-])=O)C=C4
Molecular Formula
C21H18N6O4
Molecular Weight
418.41
References & Citations
[1]Philoppes JN, et al. New pyrazolopyrimidine derivatives with anticancer activity: Design, synthesis, PIM-1 inhibition, molecular docking study and molecular dynamics. Bioorg Chem. 2020 Jul;100:103944.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PIM1
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