RNA polymerase II-IN-2
RNA polymerase II-IN-2 (compound 20iii) is a potent RNA polymerase II (Pol II) inhibitor with Ki value of 9.5 nM. RNA polymerase II-IN-2 has cytotoxicity against cancer cells, and exhibits 2 and 5 fold toxicity than α-amanitin against CHO and HEK293[1].
Product Specifications
CAS Number
2891451-33-3
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rna-polymerase-ii-in-2.html
Solubility
10 mM in DMSO
Smiles
O=C([C@H](C(CC)CC)NC(CNC1=O)=O)NCC(N[C@@H]2C(N[C@H](C(N3C[C@@H](C[C@H]3C(N[C@H](C(N[C@H]1CC4=C(S[C@H]2C)NC5=C4C=CC=C5)=O)[C@H]([C@H](CO)O)C)=O)O)=O)CC(N)=O)=O)=O
Molecular Formula
C41H58N10O12S
Molecular Weight
915.02
References & Citations
[1]Todorovic M, et al. Rationally Designed Amanitins Achieve Enhanced Cytotoxicity. J Med Chem. 2022 Jun 13.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
![KCTD9 Mouse Monoclonal Antibody [Clone ID: OTI1B9]](https://cdn.genprice.uk/products/937/68dd18b9061270361e908175/imageurl/cf807739.webp)
TRC-D229160-25MG 25 mg
21-Dehydrocorticosterone (mixture of the aldehyde and the hydrated form)
Sign In for Pricing
View Details 
