NSD2-IN-1
NSD2-IN-1 (compound 38) is a potent and high selective NSD2-PWWP1 (nuclear receptor-binding SET domain 2-PWWP1) inhibitor, with an IC50 of 0.11 μM. NSD2-IN-1 can bind to NSD2-PWWP1 and then affect the expression of genes regulated by NSD2. NSD2-IN-1 induces apoptosis and cell cycle arrest[1].
Product Specifications
CAS Number
[2797183-37-8]
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nsd2-in-1.html
Purity
98.72
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CN1C=NC(C2=C(C=C(C=C2C)CN3CCC(CC3)N)C)=C1C4=CC=C(C5=C4C=CC=C5)C#N
Molecular Formula
C29H31N5
Molecular Weight
449.59
References & Citations
[1]Li N, et al. Structure-Based Discovery of a Series of NSD2-PWWP1 Inhibitors. J Med Chem. 2022 Jun 15.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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