COX-2/PI3K-IN-2

COX-2/PI3K-IN-2 (compound 5f) is a potent PI3K inhibitor with IC50 value of 2.78 nM. COX-2/PI3K-IN-2 is a selective COX-2 inhibitor with Ki value of 3.02 nM. COX-2/PI3K-IN-2 shows anti-inflammatory and anti-cancer properties[1].

Product Specifications

CAS Number

[2459938-28-2]

UNSPSC

12352005

Target

COX; PI3K

Type

Reference compound

Related Pathways

Immunology/Inflammation; PI3K/Akt/mTOR

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cox-2-pi3k-in-2.html

Solubility

10 mM in DMSO

Smiles

O=C(/N=C1C(N(CCC)C2=C\1C=CC=C2)=O)NCN3C=CN=C3

Molecular Formula

C16H17N5O2

Molecular Weight

311.34

References & Citations

[1]Rajesh Kumar M, et al. p-TSA.H2O mediated one-pot, multi-component synthesis of isatin derived imidazoles as dual-purpose drugs against inflammation and cancer. Bioorg Chem. 2020 Sep;102:104046.