COX-2/PI3K-IN-1
COX-2/PI3K-IN-1 (compound 5d) is a potent PI3K inhibitor with IC50 value of 1.14 nM. COX-2/PI3K-IN-1 is a selective COX-2 inhibitor with Ki value of 3.24 nM. COX-2/PI3K-IN-1 has anti-inflammatory and anti-cancer properties.
Product Specifications
UNSPSC
12352005
Target
COX; PI3K
Type
Reference compound
Related Pathways
Immunology/Inflammation; PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cox-2-pi3k-in-1.html
Solubility
10 mM in DMSO
Smiles
S=C(/N=C1C(N(C2=CC=CC=C2Cl)C3=C\1C=CC=C3)=S)NCN4C=CN=C4
Molecular Formula
C19H14ClN5S2
Molecular Weight
411.93
References & Citations
[1]Rajesh Kumar M, et al. p-TSA.H2O mediated one-pot, multi-component synthesis of isatin derived imidazoles as dual-purpose drugs against inflammation and cancer. Bioorg Chem. 2020 Sep;102:104046.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
COX-2; PI3K
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