HIV-IN-5

HIV-IN-5 (compound 5r) is a potent HIV-1 inhibitor, with an IC50 of 0.16 μM. HIV-IN-5 shows inhibition of HIV DNA-dependent DNA polymerization activity, with an IC50 of 2.18 μM. HIV-IN-5 can bind to NNIBP (NNRTIs (non-nucleoside reverse transcriptase inhibitors) binding pocket) [1].

Product Specifications

CAS Number

[2459929-62-3]

UNSPSC

12352005

Target

HIV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/hiv-in-5.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC=C(OCO2)C2=C1)OC3=CC=C(C(CSC4=NC(CC5=CC=C(OCO6)C6=C5)=C(CC)C(N4)=O)=O)C=C3

Molecular Formula

C30H24N2O8S

Molecular Weight

572.59

References & Citations

[1]Yi-MingLi, et al. Design, synthesis and anti-HIV evaluation of 5-alkyl- 6- (benzo[d][1,3]dioxol-5-alkyl) -2-mercaptopyrimidin-4 (3H) -ones as potent HIV-1 NNRTIs. September 2020;102:104041.