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Aldose reductase-IN-6

Aldose reductase-IN-6 (Compound 3) is a competitive aldose reductase (AR) inhibitor with an IC50 of 3.164 μM and a Ki of 0.018 μM. Aldose reductase-IN-6 exhibits no cytotoxicity against healthy cells[1].

Product Specifications

CAS Number

2470019-41-9

UNSPSC

12352005

Target

Aldose Reductase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/aldose-reductase-in-6.html

Solubility

10 mM in DMSO

Smiles

N#CC1=CC=C(C2=CSC(N/N=C/C3=CC=C(OCCCO4)C4=C3)=N2)C=C1

Molecular Formula

C20H16N4O2S

Molecular Weight

376.43

References & Citations

[1]Sever B, et al. Design, synthesis, in vitro and in silico investigation of aldose reductase inhibitory effects of new thiazole-based compounds. Bioorg Chem. 2020 Sep;102:104110.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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