VEGFR-2-IN-22

VEGFR-2-IN-22 (Compound 25) is a dual VEGFR-2 and β-tubulin polymerization inhibitor with an IC50 of 19.82 nM against VEGFR-2. VEGFR-2-IN-22 induces apoptosis[1].

Product Specifications

CAS Number

[2447587-73-5]

UNSPSC

12352005

Target

Apoptosis; Microtubule/Tubulin; VEGFR

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/vegfr-2-in-22.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=NN(C2=CC=C(F)C(Cl)=C2)C(C3=CC(OC)=C(OC)C(OC)=C3)=N1)NC4=CC=C(OC)C(OC)=C4

Molecular Formula

C26H24ClFN4O6

Molecular Weight

542.94

References & Citations

[1]Abdelhameid MK, et al. Design, synthesis, and cytotoxic screening of novel azole derivatives on hepatocellular carcinoma (HepG2 Cells) . Bioorg Chem. 2020 Aug;101:103995.