VEGFR-2-IN-22
Product Specifications
UNSPSC Description
VEGFR-2-IN-22 (Compound 25) is a dual VEGFR-2 and β-tubulin polymerization inhibitor with an IC50 of 19.82 nM against VEGFR-2. VEGFR-2-IN-22 induces apoptosis[1].
Target Antigen
Apoptosis; Microtubule/Tubulin; VEGFR
Type
Reference compound
Related Pathways
Apoptosis;Cell Cycle/DNA Damage;Cytoskeleton;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/vegfr-2-in-22.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=NN(C2=CC=C(F)C(Cl)=C2)C(C3=CC(OC)=C(OC)C(OC)=C3)=N1)NC4=CC=C(OC)C(OC)=C4
Molecular Weight
542.94
References & Citations
[1]Abdelhameid MK, et al. Design, synthesis, and cytotoxic screening of novel azole derivatives on hepatocellular carcinoma (HepG2 Cells). Bioorg Chem. 2020 Aug;101:103995.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-147872/VEGFR-2-IN-22-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-147872/
Clinical Information
No Development Reported
CAS Number
2447587-73-5
Curated Selection
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