VEGFR-2-IN-22
VEGFR-2-IN-22 (Compound 25) is a dual VEGFR-2 and β-tubulin polymerization inhibitor with an IC50 of 19.82 nM against VEGFR-2. VEGFR-2-IN-22 induces apoptosis[1].
Product Specifications
CAS Number
2447587-73-5
UNSPSC
12352005
Target
Apoptosis; Microtubule/Tubulin; VEGFR
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/vegfr-2-in-22.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=NN(C2=CC=C(F)C(Cl)=C2)C(C3=CC(OC)=C(OC)C(OC)=C3)=N1)NC4=CC=C(OC)C(OC)=C4
Molecular Formula
C26H24ClFN4O6
Molecular Weight
542.94
References & Citations
[1]Abdelhameid MK, et al. Design, synthesis, and cytotoxic screening of novel azole derivatives on hepatocellular carcinoma (HepG2 Cells) . Bioorg Chem. 2020 Aug;101:103995.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
VEGFR2/KDR/Flk-1
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