COX-2-IN-22

COX-2-IN-22 (Compound 4h) is a COX-2 inhibitor with an IC50 of 8.6 µM. COX-2-IN-22 also inhibits AChE, BChE, β-Secretase, LOX-5 and DPPH with IC50 values of 2.8, 6.3, 15.3, 13.9 and 6.8 µM, respectively. COX-2-IN-22 can cross BBB[1].

Product Specifications

CAS Number

[2447589-08-2]

UNSPSC

12352005

Target

Beta-secretase; Cholinesterase (ChE) ; COX

Type

Reference compound

Related Pathways

Immunology/Inflammation; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cox-2-in-22.html

Solubility

10 mM in DMSO

Smiles

O=C1C=C(/C=C/C2=CC(OC)=CC(OC)=C2)C3=C(C4=C(OC(C5=CC(OC)=CC(OC)=C5)=C4)C=C3)O1

Molecular Formula

C29H24O7

Molecular Weight

484.50

References & Citations

[1]Agbo EN, et al. Synthesis of furocoumarin-stilbene hybrids as potential multifunctional drugs against multiple biochemical targets associated with Alzheimer's disease. Bioorg Chem. 2020 Aug;101:103997.