COX-2-IN-22
Product Specifications
UNSPSC Description
COX-2-IN-22 (Compound 4h) is a COX-2 inhibitor with an IC50 of 8.6 µM. COX-2-IN-22 also inhibits AChE, BChE, β-Secretase, LOX-5 and DPPH with IC50 values of 2.8, 6.3, 15.3, 13.9 and 6.8 µM, respectively. COX-2-IN-22 can cross BBB[1].
Target Antigen
Beta-secretase; Cholinesterase (ChE); COX
Type
Reference compound
Related Pathways
Immunology/Inflammation;Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cox-2-in-22.html
Solubility
10 mM in DMSO
Smiles
O=C1C=C(/C=C/C2=CC(OC)=CC(OC)=C2)C3=C(C4=C(OC(C5=CC(OC)=CC(OC)=C5)=C4)C=C3)O1
Molecular Weight
484.50
References & Citations
[1]Agbo EN, et al. Synthesis of furocoumarin-stilbene hybrids as potential multifunctional drugs against multiple biochemical targets associated with Alzheimer's disease. Bioorg Chem. 2020 Aug;101:103997.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-147870/COX-2-IN-22-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-147870/
Clinical Information
No Development Reported
CAS Number
2447589-08-2
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