HBV-IN-24

HBV-IN-24 (compound (2ʹS, 6S) -1a) is a potent HBV inhibitor. HBV-IN-24 exhibits potent inhibition activity against HBV DNA, HBsAg, and HBeAg, with EC50 values of 0.6, 0.6, and 4.6 nM, respectively. HBV-IN-24 shows excellent antiviral activity, could have improved neurotoxicity[1].

Product Specifications

UNSPSC

12352005

Target

HBV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/hbv-in-24.html

Solubility

10 mM in DMSO

Smiles

COC1=C(C=C2C[C@H](N3C=C(C(C=C3C2=C1)=O)C(O)=O)C(C)C)OC[C@@H]4CCCO4

Molecular Formula

C23H27NO6

Molecular Weight

413.46

References & Citations

[1]Qin X, et al. Identification of dihydroquinolizinone derivatives with cyclic ether moieties as new anti-HBV agents. Eur J Med Chem. 2022 Aug 5;238:114518.