Topoisomerase II inhibitor 11
Selected Variant
HY-147861
Size: 1 Each
Topoisomerase II inhibitor 11 (compound 3d) is a potent Topoisomerase II inhibitor, with an IC50 of 2.89 μM. Topoisomerase II inhibitor 11 shows 92.46% inhibition on renal cancer cell line A498 with an IC50 of 3.5 μM. Topoisomerase II inhibitor 11 causes cell cycle arrest at the G2/M phase leading to cell proliferation inhibition and pro-apoptotic activity[1].
Product Specifications
CAS Number
2476559-00-7
UNSPSC
12352005
Target
Apoptosis; Topoisomerase
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/topoisomerase-ii-inhibitor-11.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(C2=CC=CC=C2)N=C(SC=C3C4=CC=C(Cl)C=C4)N3C1C5=CC=C(Cl)C=C5)OCC.[H]Br
Molecular Formula
C27H21BrCl2N2O2S
Molecular Weight
588.34
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Topo II
Price
Frequently Asked Questions
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