BACE1-IN-12

BACE1-IN-12 (compound 7g) is a potent and BBB-penetrated BACE1 inhibitor, with an IC50 of 8.9 µM. BACE1-IN-12 shows selective BuChE (butyrylcholinesterase) inhibitory activity with an IC50 of 3.2 µM. BACE1-IN-12 shows effective antioxidant effect with an IC50 of 10.2 μM (DPPH) . BACE1-IN-12 might be served as a potential anti-Alzheimer agent[1].

Product Specifications

CAS Number

[2479315-19-8]

UNSPSC

12352005

Target

Beta-secretase

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/bace1-in-12.html

Solubility

10 mM in DMSO

Smiles

ClC1=CC=C(CN2N=NC(COC3=CC=C(C4=C(NC5CCCCC5)N6C=CC=CC6=N4)C=C3)=C2)C=C1Cl

Molecular Formula

C29H28Cl2N6O

Molecular Weight

547.48

References & Citations

[1]Haghighijoo Z, et al. N-Cyclohexylimidazo[1,2-a]pyridine derivatives as multi-target-directed ligands for treatment of Alzheimer's disease. Bioorg Chem. 2020 Oct;103:104146.