Tubulin polymerization-IN-27
Tubulin polymerization-IN-27 (compound 5j) is a tubulin polymerization inhibitor. Tubulin polymerization-IN-27 can arrest cell cycle at G2/M phase and induce apoptosis[1].
Product Specifications
CAS Number
2462030-32-4
UNSPSC
12352005
Target
Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tubulin-polymerization-in-27.html
Solubility
10 mM in DMSO
Smiles
COC1=C2C=CC=CC2=C(C3=NNC=C3C4=CC=C(OCC)C=C4)C=C1
Molecular Formula
C22H20N2O2
Molecular Weight
344.41
References & Citations
[1]Wang G, et, al. Design, synthesis, molecular modeling, and biological evaluation of pyrazole-naphthalene derivatives as potential anticancer agents on MCF-7 breast cancer cells by inhibiting tubulin polymerization. Bioorg Chem. 2020 Oct;103:104141.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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