Tubulin polymerization-IN-27

Tubulin polymerization-IN-27 (compound 5j) is a tubulin polymerization inhibitor. Tubulin polymerization-IN-27 can arrest cell cycle at G2/M phase and induce apoptosis[1].

Product Specifications

CAS Number

[2462030-32-4]

UNSPSC

12352005

Target

Microtubule/Tubulin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tubulin-polymerization-in-27.html

Solubility

10 mM in DMSO

Smiles

COC1=C2C=CC=CC2=C(C3=NNC=C3C4=CC=C(OCC)C=C4)C=C1

Molecular Formula

C22H20N2O2

Molecular Weight

344.41

References & Citations

[1]Wang G, et, al. Design, synthesis, molecular modeling, and biological evaluation of pyrazole-naphthalene derivatives as potential anticancer agents on MCF-7 breast cancer cells by inhibiting tubulin polymerization. Bioorg Chem. 2020 Oct;103:104141.