Topoisomerase II inhibitor 10
Product Specifications
UNSPSC Description
Topoisomerase II inhibitor 10 (compound 32a) is a potent topoisomerase II inhibitor with an IC50 value of 7.45 μM. Topoisomerase II inhibitor 10 causes cell cycle arrest at G2-M phase and induces apoptosis of HepG-2 cells. Topoisomerase II inhibitor 10 has excellent anti-proliferative activities against HepG-2, MCF-7, and HCT-116 cells[1].
Target Antigen
Apoptosis; Topoisomerase
Type
Reference compound
Related Pathways
Apoptosis;Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/topoisomerase-ii-inhibitor-10.html
Solubility
10 mM in DMSO
Smiles
O=C(O)C1=CC=C(NC(CSC2=NN=C3N2N(CC(NC4=CC=C(C(O)=O)C=C4)=O)C(C5=C3C=CC=C5)=O)=O)C=C1
Molecular Weight
572.55
References & Citations
[1]El-Helby AA, et al. Design, synthesis, molecular modeling, in vivo studies and anticancer activity evaluation of new phthalazine derivatives as potential DNA intercalators and topoisomerase II inhibitors. Bioorg Chem. 2020 Oct;103:104233.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-147839/Topoisomerase-II-inhibitor-10-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-147839/
Clinical Information
No Development Reported
CAS Number
2488208-96-2
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