Akt/NF-κB/JNK-IN-1

Akt/NF-κB/JNK-IN-1 (Compound 2i) is an inhibitor of Akt, NF-κB and JNK signaling pathways. Akt/NF-κB/JNK-IN-1 inhibits nitric oxide production with an IC50 of 3.15 μM. Akt/NF-κB/JNK-IN-1 shows anti-inflammatory activities[1].

Product Specifications

UNSPSC

12352005

Target

Akt; COX; JNK; NF-κB; TNF Receptor

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; NF-κB; PI3K/Akt/mTOR

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/akt-nf-κb-jnk-in-1.html

Solubility

10 mM in DMSO

Smiles

CN1CCN(CC1)CC(OCC2=CC3=C(C(O)=C2)C(C4=C(C=CC=C4C3=O)O)=O)=O

Molecular Formula

C22H22N2O6

Molecular Weight

410.42

References & Citations

[1]Shang H, et al. Design, synthesis and anti-inflammatory evaluation of aloe-emodin derivatives as potential modulators of Akt, NF-κB and JNK signaling pathways. Eur J Med Chem. 2022 Aug 5;238:114511.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

COX-2; TNFRSF5/CD40

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