Akt/NF-κB/JNK-IN-1
Akt/NF-κB/JNK-IN-1 (Compound 2i) is an inhibitor of Akt, NF-κB and JNK signaling pathways. Akt/NF-κB/JNK-IN-1 inhibits nitric oxide production with an IC50 of 3.15 μM. Akt/NF-κB/JNK-IN-1 shows anti-inflammatory activities[1].
Product Specifications
UNSPSC
12352005
Target
Akt; COX; JNK; NF-κB; TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; NF-κB; PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/akt-nf-κb-jnk-in-1.html
Solubility
10 mM in DMSO
Smiles
CN1CCN(CC1)CC(OCC2=CC3=C(C(O)=C2)C(C4=C(C=CC=C4C3=O)O)=O)=O
Molecular Formula
C22H22N2O6
Molecular Weight
410.42
References & Citations
[1]Shang H, et al. Design, synthesis and anti-inflammatory evaluation of aloe-emodin derivatives as potential modulators of Akt, NF-κB and JNK signaling pathways. Eur J Med Chem. 2022 Aug 5;238:114511.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
COX-2; TNFRSF5/CD40
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