Akt/NF-κB/JNK-IN-1
Product Specifications
UNSPSC Description
Akt/NF-κB/JNK-IN-1 (Compound 2i) is an inhibitor of Akt, NF-κB and JNK signaling pathways. Akt/NF-κB/JNK-IN-1 inhibits nitric oxide production with an IC50 of 3.15 μM. Akt/NF-κB/JNK-IN-1 shows anti-inflammatory activities[1].
Target Antigen
Akt; COX; JNK; NF-κB; TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis;Immunology/Inflammation;MAPK/ERK Pathway;NF-κB;PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/akt-nf-κb-jnk-in-1.html
Solubility
10 mM in DMSO
Smiles
CN1CCN(CC1)CC(OCC2=CC3=C(C(O)=C2)C(C4=C(C=CC=C4C3=O)O)=O)=O
Molecular Weight
410.42
References & Citations
[1]Shang H, et al. Design, synthesis and anti-inflammatory evaluation of aloe-emodin derivatives as potential modulators of Akt, NF-κB and JNK signaling pathways. Eur J Med Chem. 2022 Aug 5;238:114511.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-147836/Akt-NF-κB-JNK-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-147836/
Clinical Information
No Development Reported
Curated Selection
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