STING agonist-9

STING agonist-9 (Compound 45) is a potent STING agonist with an EC50 of 1.2 nM and 32.82 μM against h-STING and m-STING, respectively. STING agonist-9 shows antitumor activity[1].

Product Specifications

CAS Number

[2653337-73-4]

UNSPSC

12352005

Target

STING

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sting-agonist-9.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC(OCCCN2CCOCC2)=C3C(N=C(NC(C4=CC(C)=NN4CC)=O)N3C/C=C/CN5C(NC(C6=CC(C)=NN6CC)=O)=NC7=C5SC(C(N)=O)=C7)=C1)N

Molecular Formula

C39H47N13O6S

Molecular Weight

825.94

References & Citations

[1]Niu J, et al. Discovery of novel Thieno[2,3-d]imidazole derivatives as agonists of human STING for antitumor immunotherapy using systemic administration. Eur J Med Chem. 2022 Aug 5;238:114482.