ALK-IN-22

ALK-IN-22 (compound I-24) is a potent ALK inhibitor with IC50 values of 2.3, 3.7 and 2.9 nM for ALK, ALKL1196M and ALKG1202R, respectively. ALK-IN-22 down-regulated the phosphorylation of ALK and its downstream proteins. ALK-IN-22 induces apoptosis. ALK-IN-22 can be used for tumor research[1].

Product Specifications

CAS Number

[2468219-09-0]

UNSPSC

12352005

Target

Anaplastic lymphoma kinase (ALK) ; Apoptosis

Type

Reference compound

Related Pathways

Apoptosis; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/alk-in-22.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=C(C)NC2=C1C=CC(NC3=NC=C(Cl)C(NC4=CC=CC=C4C(NC)=O)=N3)=C2)N(C)C

Molecular Formula

C24H24ClN7O2

Molecular Weight

477.95

References & Citations

[1]Thacker PS, et al. Synthesis and biological evaluation of some coumarin hybrids as selective carbonic anhydrase IX and XII inhibitors. Bioorg Chem. 2020 Nov;104:104272.