EGFR/BRAFV600E-IN-1
Product Specifications
UNSPSC Description
EGFR/BRAFV600E-IN-1 (Compound 23) is a potent EGFR and BRAFV600E dual inhibitor with IC50s of 0.08 and 0.15 µM, respectively. EGFR/BRAFV600E-IN-1 induces apoptosis and cell cycle arrest in both pre-G1 and G2/M phases. EGFR/BRAFV600E-IN-1 exhibits antiproliferative activity againist A-549, MCF-7, Panc-1, HT-29 with IC50s of 1.2, 0.79, 1.3, and 1.23 µM, respectively[1].
Target Antigen
Apoptosis; EGFR; Raf
Type
Reference compound
Related Pathways
Apoptosis;JAK/STAT Signaling;MAPK/ERK Pathway;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-brafv600e-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C1N(CCC2=CC=C(N3CCOCC3)C=C2)CC(N4C1=C(C)C5=C4C=CC(Cl)=C5)=O
Molecular Weight
437.92
References & Citations
[1]Lamya H Al-Wahaibi, et al. Design and synthesis of novel 2,3-dihydropyrazino[1,2-a]indole-1,4-dione derivatives as antiproliferative EGFR and BRAF V600E dual inhibitors. Bioorg Chem. 2020 Nov;104:104260.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-147825/EGFR-BRAFV600E-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-147825/
Clinical Information
No Development Reported
CAS Number
2492429-45-3
Curated Selection
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