Levomefolic acid-13C5

Levomefolic acid-13C5 is the 13C labeled Levomefolic acid[1]. Levomefolic acid (L-5-MTHF) is an orally active, brain-penetrant natural active form of folic acid and is one of the most widely used folic acid food supplements[2][3].

Product Specifications

CAS Number

[2687960-08-1]

Product Name Alternative

L-5-MTHF-13C5

UNSPSC

12352005

Target

DNA/RNA Synthesis; Endogenous Metabolite; Reactive Oxygen Species (ROS)

Type

Isotope-Labeled Compounds

Related Pathways

Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/levomefolic-acid-13c5.html

Solubility

10 mM in DMSO

Smiles

O=[13C](O)[13CH2][13CH2][13C@@H]([13C](O)=O)NC(C1=CC=C(NC[C@@H]2N(C)C3=C(NC(N)=NC3=O)NC2)C=C1)=O

Molecular Formula

C15 13C5H25N7O6

Molecular Weight

464.42

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Manisha Prajapat, et al. Virtual screening and molecular dynamics study of approved drugs as inhibitors of spike protein S1 domain and ACE2 interaction in SARS-CoV-2. J Mol Graph Model. 2020 Dec;101:107716.|[3]Maša Vidmar Golja, et al. Simultaneous quantification of intracellular concentrations of clinically important metabolites of folate-homocysteine cycle by LC-MS/MS. Anal Biochem. 2020 Sep 15;605:113830.