COX-2-IN-21
COX-2-IN-21 (Compound 5c) is a selective and orally active COX-2 inhibitor with an IC50 of 0.039 μM. COX-2-IN-21 shows promising anti-inflammatory potential[1].
Product Specifications
CAS Number
2519631-11-7
UNSPSC
12352005
Target
COX
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cox-2-in-21.html
Solubility
10 mM in DMSO
Smiles
CC(N1N=C(C2=CC=CC(N3N=NN=C3)=C2)CC1C4=CC(OC)=C(OC)C(OC)=C4)=O
Molecular Formula
C21H22N6O4
Molecular Weight
422.44
References & Citations
[1]Labib MB, et al. Novel tetrazole-based selective COX-2 inhibitors: Design, synthesis, anti-inflammatory activity, evaluation of PGE2, TNF-α, IL-6 and histopathological study. Bioorg Chem. 2020 Nov;104:104308.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
COX-1; COX-2
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