HIF-1α-IN-3
HIF-1α-IN-3 (Compound (S) -3f) is a hypoxia-selective HIF-1α inhibitor. HIF-1α-IN-3 shows strong antiestrogenic potency[1].
Product Specifications
CAS Number
2170715-64-5
UNSPSC
12352005
Target
HIF/HIF Prolyl-Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hif-1α-in-3.html
Solubility
10 mM in DMSO
Smiles
N#CC1=C(C2=CC=CC=C2)[N+]([O-])=C3C=CC(N4C[C@@H](N)CC4)=CC3=[N+]1[O-]
Molecular Formula
C19H17N5O2
Molecular Weight
347.37
References & Citations
[1]Buravchenko GI, et al. Discovery of derivatives of 6 (7) -amino-3-phenylquinoxaline-2-carbonitrile 1,4-dioxides: novel, hypoxia-selective HIF-1α inhibitors with strong antiestrogenic potency. Bioorg Chem. 2020 Nov;104:104324.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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