Topoisomerase IIα-IN-3
Topoisomerase IIα-IN-3 (Compound 12c) is a DNA intercalative topoisomerase-IIα inhibitor. Topoisomerase IIα-IN-3 arrests cell cycle at the G0/G1 phase and induces apoptosis[1].
Product Specifications
CAS Number
[2538528-11-7]
UNSPSC
12352005
Target
Apoptosis; Topoisomerase
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/topoisomerase-iiα-in-3.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC2=C(C(C3=CC=C(OC)C=C3)=N1)NC4=C2C=CC=C4)NC5=NN=C(C(N6)=CC7=C6C=CC=C7)S5
Molecular Formula
C29H20N6O2S
Molecular Weight
516.57
References & Citations
[1]Tokala R, et al. Design and synthesis of thiadiazolo-carboxamide bridged β-carboline-indole hybrids: DNA intercalative topo-IIα inhibition with promising antiproliferative activity. Bioorg Chem. 2020 Dec;105:104357.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Topo II
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