Riociguat-13C, d6

Riociguat-13C, d6 is the 13C and deuterium labeled Riociguat (HY-14779) . Riociguat is an oral stimulator of soluble guanylate cyclase (sGC) used in the treatment of pulmonary hypertension.

Product Specifications

Product Name Alternative

BAY 632521-13C, d6

UNSPSC

12352005

Target

Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Others

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Purity

99.0

Solubility

10 mM in DMSO|DMF : ≥ 10mg/mL|DMSO : ≥ 10mg/mL

Smiles

O=C(OC([2H])([2H])[2H])N(C1=C(N)N=C(C2=NN(CC3=CC=CC=C3F)C4=NC=CC=C42)N=C1N)[13C]([2H])([2H])[2H]

Molecular Formula

C19 13CH13D6FN8O2

Molecular Weight

429.45

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-223.|[2]Schermuly RT, et al. Expression and function of soluble guanylate cyclase in pulmonary arterial hypertension. Eur Respir J. 2008 Oct;32 (4) :881-91. |[3]Schermuly RT, et al. Riociguat for the treatment of pulmonary hypertension.Expert Opin Investig Drugs. 2011 Apr;20 (4) :567-76.