Riociguat-13C, d6
Riociguat-13C, d6 is the 13C and deuterium labeled Riociguat (HY-14779) . Riociguat is an oral stimulator of soluble guanylate cyclase (sGC) used in the treatment of pulmonary hypertension.
Product Specifications
Product Name Alternative
BAY 632521-13C, d6
UNSPSC
12352005
Target
Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Others
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Purity
99.0
Solubility
10 mM in DMSO|DMF : ≥ 10mg/mL|DMSO : ≥ 10mg/mL
Smiles
O=C(OC([2H])([2H])[2H])N(C1=C(N)N=C(C2=NN(CC3=CC=CC=C3F)C4=NC=CC=C42)N=C1N)[13C]([2H])([2H])[2H]
Molecular Formula
C19 13CH13D6FN8O2
Molecular Weight
429.45
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-223.|[2]Schermuly RT, et al. Expression and function of soluble guanylate cyclase in pulmonary arterial hypertension. Eur Respir J. 2008 Oct;32 (4) :881-91. |[3]Schermuly RT, et al. Riociguat for the treatment of pulmonary hypertension.Expert Opin Investig Drugs. 2011 Apr;20 (4) :567-76.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
Phase 4
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