HCA XII/II/IX-IN-1
HCA XII/II/IX-IN-1 (Compound 3) is a potent human carbonic anhydrase (hCA) inhibitor with IC50 values of 2.6, 0.004, 0.005 and 0.001 μM against hCA I, hCA II, hCA IX and hCA XII, respectively. hCA XII/II/IX-IN-1 shows anticancer activity[1].
Product Specifications
UNSPSC
12352005
Target
Carbonic Anhydrase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hca-xii-ii-ix-in-1.html
Solubility
10 mM in DMSO
Smiles
C[C@H]1[C@@]2([H])[C@@]34[C@]([H])([C@H]([C@H](O[C@@H]3O[C@@](C)(CC2)OO4)OCCC5=CN(C6=CC=C(S(=O)(N)=O)C=C6)N=N5)C)CC1
Molecular Formula
C25H34N4O7S
Molecular Weight
534.63
References & Citations
[1]An R, et al. Discovery of novel artemisinin-sulfonamidehybrids as potential carbonicanhydraseIX inhibitors with improved antiproliferative activities. Bioorg Chem. 2020 Nov;104:104347.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CA IX; CA XII
Frequently Asked Questions
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