EGFR/HER2/CDK9-IN-2
EGFR/HER2/CDK9-IN-2 (Compound 9) is a potent inhibitor of EGFR/HER2/CDK9 with IC50s of 145.35, 129.07, and 117.13 nM, respectively. EGFR/HER2/CDK9-IN-2 exhibits remarkable antitumor activity[1].
Product Specifications
CAS Number
1180924-34-8
UNSPSC
12352005
Target
CDK; EGFR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-her2-cdk9-in-2.html
Solubility
10 mM in DMSO
Smiles
O=S(C1=CC=C(CCN2C(SCC3=CC=C([N+]([O-])=O)C=C3)=NC4=C(C=CC=C4)C2=O)C=C1)(N)=O
Molecular Formula
C23H20N4O5S2
Molecular Weight
496.56
References & Citations
[1] El-Azab AS, et al. Antitumor activity, multitarget mechanisms, and molecular docking studies of quinazoline derivatives based on a benzenesulfonamide scaffold: Cell cycle analysis. Bioorg Chem. 2020;104:104345.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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