EGFR/HER2/CDK9-IN-2

EGFR/HER2/CDK9-IN-2 (Compound 9) is a potent inhibitor of EGFR/HER2/CDK9 with IC50s of 145.35, 129.07, and 117.13 nM, respectively. EGFR/HER2/CDK9-IN-2 exhibits remarkable antitumor activity[1].

Product Specifications

CAS Number

[1180924-34-8]

UNSPSC

12352005

Target

CDK; EGFR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/egfr-her2-cdk9-in-2.html

Solubility

10 mM in DMSO

Smiles

O=S(C1=CC=C(CCN2C(SCC3=CC=C([N+]([O-])=O)C=C3)=NC4=C(C=CC=C4)C2=O)C=C1)(N)=O

Molecular Formula

C23H20N4O5S2

Molecular Weight

496.56

References & Citations

[1] El-Azab AS, et al. Antitumor activity, multitarget mechanisms, and molecular docking studies of quinazoline derivatives based on a benzenesulfonamide scaffold: Cell cycle analysis. Bioorg Chem. 2020;104:104345.