FPDT

FPDT is an anti-glioblastoma agent. FPDT displays the IC50 value of 45–68 μM for GBM cells and >100 μM for astrocytes. Anti-glioblastoma activity of FPDT is linked to downregulation of the AKT pathway[1].

Product Specifications

UNSPSC

12352005

Target

Akt

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/fpdt.html

Solubility

10 mM in DMSO

Smiles

OC1=CC=C(C(O)=C1)C2=CC=C(S2)NC3=CC=C(C=C3)F

Molecular Formula

C16H12FNO2S

Molecular Weight

301.34

References & Citations

[1]Szeliga M, et al. Design, synthesis and biological evaluation of novel 1,3,4-thiadiazole derivatives as anti-glioblastoma agents targeting the AKT pathway. Bioorg Chem. 2020;105:104362.