HDHODH-IN-9

HDHODH-IN-9 (Compound 3k) is a potent inhibitor of hDHODH with an IC50 of 0.34 μM. hDHODH-IN-9 demonstrates high cytotoxic activity against MCF-7 and A375 cells and good selectivity. hDHODH-IN-9 has the potential for the research of cancer diseases[1].

Product Specifications

CAS Number

[133676-47-8]

UNSPSC

12352005

Target

Dihydroorotate Dehydrogenase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hdhodh-in-9.html

Solubility

10 mM in DMSO

Smiles

CCCCOC1=CC=C(C=C1OC)C2=NC3=CC=CC=C3C(C(O)=O)=C2

Molecular Formula

C21H21NO4

Molecular Weight

351.40

References & Citations

[1]Petrović MM, et al. Potent human dihydroorotate dehydrogenase inhibitory activity of new quinoline-4-carboxylic acids derived from phenolic aldehydes: Synthesis, cytotoxicity, lipophilicity and molecular docking studies. Bioorg Chem. 2020;105:104373.