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NAAA-IN-3

NAAA-IN-3 (Compound 17a) is a potent and selective inhibitor of NAAA with an IC50 of 50 nM. NAAA is a cysteine amidase which preferentially hydrolyzes the endogenous biolipids palmitoylethanolamide (PEA) and oleoylethanolamide (OEA) . NAAA-IN-3 has the potential for the research of inflammation and pain[1].

Product Specifications

CAS Number

[1831115-59-3]

UNSPSC

12352005

Target

Ceramidase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/naaa-in-3.html

Purity

98.20

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

N#CN1CC(C1)OCC2=CC=C(C=C2)C3=CC=CC=C3

Molecular Formula

C17H16N2O

Molecular Weight

264.32

References & Citations

[1]Malamas MS, et al. Design and synthesis of cyanamides as potent and selective N-acylethanolamine acid amidase inhibitors. Bioorg Med Chem. 2020 Jan 1;28 (1) :115195.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-147775/NAAA-IN-3-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-147775/NAAA-IN-3-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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