ZC0101

ZC0101 is a potent, orally active IDO1 and TrxR dual inhibitor with IC50 values of 0.084 μM and 7.98 μM, respectively. ZC0101 effectively induces apoptosis and ROS accumulation in cancer cells[1].

Product Specifications

CAS Number

[2541604-52-6]

UNSPSC

12352005

Target

Apoptosis; Indoleamine 2,3-Dioxygenase (IDO) ; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/zc0101.html

Solubility

10 mM in DMSO

Smiles

O=C1C=CCCN1C(/C=C/C2=CC=CC=C2C3=CNC=N3)=O

Molecular Formula

C17H15N3O2

Molecular Weight

293.32

References & Citations

[1]Fan QZ, et al. Design, synthesis, and biological evaluation of a novel indoleamine 2,3-dioxigenase 1 (IDO1) and thioredoxin reductase (TrxR) dual inhibitor. Bioorg Chem. 2020 Dec;105:104401.