NF-κB-IN-6
NF-κB-IN-6 (Compound 3d) is an anti-inflammatory agent through the mechanism of decreasing the protein expressions of iNOS and COX-2 by suppressing NF-κB signaling pathway. NF-κB-IN-6 inhibits NO production in LPS-induced RAW264.7 cells with an IC50 of 23.1 μM[1].
Product Specifications
UNSPSC
12352005
Target
NF-κB
Type
Reference compound
Related Pathways
NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nf-κb-in-6.html
Solubility
10 mM in DMSO
Smiles
[H][C@]12CC=C(CO)[C@@]1([H])C3N(C)CCN3C=C2C(OC)=O
Molecular Formula
C14H20N2O3
Molecular Weight
264.32
References & Citations
[1]Li SM, et al. Bioactivity Study of Tricyclic and Tetracyclic Genipin Derivatives as Anti-inflammatory Agents. Bioorg Chem. 2022 Sep;126:105881.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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