Dyrk1A-IN-2
Dyrk1A-IN-2 (Compound 63) is a DYRK1A inhibitor with an EC50 of 37 nM. Dyrk1A-IN-2 exhibits highly potent human β-cell replication-promoting activity and low cytotoxicity[1].
Product Specifications
CAS Number
2459657-37-3
UNSPSC
12352005
Target
DYRK
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/dyrk1a-in-2.html
Solubility
10 mM in DMSO
Smiles
CCOC(C1=C(C2=NC(C3=CC(N)=NC=C3)=CC=C2N=C1)N[C@@H]4CC[C@H](CC4)CN5CCOCC5)=O
Molecular Formula
C27H34N6O3
Molecular Weight
490.60
References & Citations
[1]Allegretti PA, et al. Generation of highly potent DYRK1A-dependent inducers of human β-Cell replication via Multi-Dimensional compound optimization. Bioorg Med Chem. 2020 Jan 1;28 (1) :115193.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DYRK1
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
AP22568PU-N 50 µg
FOXA1 (429-439) goat polyclonal antibody, Aff - Purified
Sign In for Pricing
View Details 
orb2804757 100 µg
Zebrafish METTL3 Rabbit Polyclonal Antibody (FITC)
Sign In for Pricing
View Details 
bs-107461P-01 20 µg
Recombinant Human TRGV9/V¶√?9 (TCR) Protein, N-His
Sign In for Pricing
View Details