Dyrk1A-IN-2
Dyrk1A-IN-2 (Compound 63) is a DYRK1A inhibitor with an EC50 of 37 nM. Dyrk1A-IN-2 exhibits highly potent human β-cell replication-promoting activity and low cytotoxicity[1].
Product Specifications
CAS Number
2459657-37-3
UNSPSC
12352005
Target
DYRK
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/dyrk1a-in-2.html
Solubility
10 mM in DMSO
Smiles
CCOC(C1=C(C2=NC(C3=CC(N)=NC=C3)=CC=C2N=C1)N[C@@H]4CC[C@H](CC4)CN5CCOCC5)=O
Molecular Formula
C27H34N6O3
Molecular Weight
490.60
References & Citations
[1]Allegretti PA, et al. Generation of highly potent DYRK1A-dependent inducers of human β-Cell replication via Multi-Dimensional compound optimization. Bioorg Med Chem. 2020 Jan 1;28 (1) :115193.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DYRK1
Frequently Asked Questions
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