BACE1/2-IN-1
Product Specifications
UNSPSC Description
BACE1/2-IN-1 (compound 34) is a potent BACE1 and BACE2 inhibitor, with an IC50 of 0.01 and 0.0053 μM, respectively. BACE1/2-IN-1 shows a combination of lower Pgp efflux ratio and improved passive permeability. BACE1/2-IN-1 displays reduced liver microsomal metabolic stability[1].
Target Antigen
Amyloid-β; Beta-secretase
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bace1-2-in-1.html
Solubility
10 mM in DMSO
Smiles
NC1=N[C@](CN(C2=NC=CC=N2)C3)([C@]4([H])C[C@]4(C(C)(C)OC[C@@H]5C[C@H]5C)[H])[C@@H]3CS1
Molecular Weight
401.57
References & Citations
[1]Winneroski LL, et al. Preparation and biological evaluation of BACE1 inhibitors: Leveraging trans-cyclopropyl moieties as ligand efficient conformational constraints. Bioorg Med Chem. 2020 Jan 1;28(1):115194.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-147758/BACE1-2-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-147758/
Clinical Information
No Development Reported
CAS Number
2671036-34-1
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